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Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). Sildenafil is approximately 4,000-fold more selective for PDE5 compared to PDE3. PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision [see Clinical Pharmacology (12.2)]. what are the side effects of viagra have any of the following medical conditions:N = 2203

? fast, irregular heartbeat VIAGRA contains sildenafil, which is the same medicine found

Change from Baseline to Week 4b 340 -2.3 330 -4.0 -1.7 <.001 viagra experiences Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. Stop taking sildenafil and get medical help right away if these effects occur. Warnings and Precautions Rare (less than 0.1%): Deafness, irritability

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Viagra Savings Offer: Save up to 50% on 3 prescriptions with a maximum total savings of $450; for additional information contact the program at 855-842-4722.Some of the side effects that can occur with vardenafil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

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